ATP-dependent chromatin remodeling shapes the long noncoding RNA landscape
نویسندگان
چکیده
منابع مشابه
ATP-dependent chromatin remodeling shapes the long noncoding RNA landscape.
Long noncoding RNAs (lncRNAs) are pervasively transcribed across eukaryotic genomes, but functions of only a very small subset of them have been demonstrated. This has led to active debate about whether many of them have any biological functions. In addition, very few regulators of lncRNAs have been identified. We developed a novel genetic screen using reconstituted RNAi in Saccharomyces cerevi...
متن کاملChromatin remodeling by ATP-dependent molecular machines.
The eukaryotic genome is packaged into a periodic nucleoprotein structure termed chromatin. The repeating unit of chromatin, the nucleosome, consists of DNA that is wound nearly two times around an octamer of histone proteins. To facilitate DNA-directed processes in chromatin, it is often necessary to rearrange or to mobilize the nucleosomes. This remodeling of the nucleosomes is achieved by th...
متن کاملATP-dependent chromatin remodeling during mammalian development.
Precise gene expression ensures proper stem and progenitor cell differentiation, lineage commitment and organogenesis during mammalian development. ATP-dependent chromatin-remodeling complexes utilize the energy from ATP hydrolysis to reorganize chromatin and, hence, regulate gene expression. These complexes contain diverse subunits that together provide a multitude of functions, from early emb...
متن کاملATP-dependent chromatin assembly is functionally distinct from chromatin remodeling
Chromatin assembly involves the combined action of ATP-dependent motor proteins and histone chaperones. Because motor proteins in chromatin assembly also function as chromatin remodeling factors, we investigated the relationship between ATP-driven chromatin assembly and chromatin remodeling in the generation of periodic nucleosome arrays. We found that chromatin remodeling-defective Chd1 motor ...
متن کاملThe Long Noncoding RNA Landscape of the Mouse Eye.
Purpose Long noncoding RNAs (lncRNAs) are important regulators of diverse biological functions. However, an extensive in-depth analysis of their expression profile and function in mammalian eyes is still lacking. Here we describe comprehensive landscapes of stage-dependent and tissue-specific lncRNA expression in the mouse eye. Methods Affymetrix transcriptome array profiled lncRNA signatures...
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ژورنال
عنوان ژورنال: Genes & Development
سال: 2014
ISSN: 0890-9369,1549-5477
DOI: 10.1101/gad.250902.114